Latest technologies from Salk Institutehttp://salkinnovations.testtechnologypublisher.comBe the first to know about the latest inventions and technologies available from Salk Instituteen-USWed, 20 Sep 2017 12:58:56 GMTThu, 10 Apr 2014 11:56:30 GMT 2017, Salk InstituteCNB-001- a novel synthetic pyrazole derivative of curcumin with neuroprotective, anti-oxidant and anti-inflammatory action - a novel synthetic pyrazole derivative of curcumin with neuroprotective, anti-oxidant and anti-inflammatory action INVENTION: Investigators at the Salk Institute have designed, synthesized and optimized a novel pyrazole derivative of curcumin. CNB-001 displays much improved potency and metabolic stability over curcumin and is neuroprotective in multiple neurotoxicity assays in which curcumin is inactive while retaining anti-oxidant and anti-inflammatory actions. APPLICATIONS: Therapeutic indications: Stroke, Alzheimer's disease, Parkinson's disease, Traumatic Brain Injury...Thu, 10 Apr 2014 11:56:30 GMTotd@salk.edu Adenoviruses Generation of Customized Tumor-Selective Oncolytic Adenoviruses Allows for the efficient optimization of viruses for use in oncolytic viral therapies. INVENTION: The goal of oncolytic viral therapy is to specifically infect and kill tumor cells without causing damage to normal cells. Although adenovirus is one of the most commonly used gene transfer vectors in basic and pre-clinical research, their potential as effective oncolytic viruses has been greatly limited by the reliance on the common serotypes Ad2 and Ad5 and the technical difficulties associated with the manipulation ...Wed, 09 Apr 2014 19:28:52 GMTotd@salk.edu Viral Cancer Immunotherapy Viral Cancer Immunotherapy Modular construction of targeted, systemically delivered oncolytic adenovirus for immunotherapy of cancer. INVENTION: Oncolytic viruses are exquisite tumor-selective, multi-mechanistic antitumor agents that can kill cancer cells, not just through direct oncolysis, but also via immunogenic cell death. These viruses are growing in importance as agents to stimulate the antitumor immune response, break immune tolerance in the tumor microenvironment, and as vehicles to deliver tumor antigens and immuno-stimulatory agents for vaccines. Multimodal immunoge...Wed, 09 Apr 2014 19:28:51 GMTotd@salk.edu Tumor Diagnostics, 09 Apr 2014 19:28:51 GMTotd@salk.edu Assembly Method Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several applications has been greatly hindered by the inability to manipulate the 36kb viral genome rapidly and systematically. In addition, the adenoviral vectors currently in use are generally limited to 2 adenovirus (Ad) serotypes 2 and 5, which restrict...Wed, 09 Apr 2014 19:28:50 GMTotd@salk.edu - a novel gene indispensible for multiciliate cell differentiation, 28 Mar 2014 12:05:13 GMTotd@salk.edu (LIM homeobox 2) conditional knock-out mice (Lhx2 floxed), 28 Mar 2014 12:05:11 GMTotd@salk.edu of EIN2 Protein to Promote Fruit Ripening and Increase Plant Biomass, 17 Feb 2014 15:03:13 GMTotd@salk.edu Novel Transcription Factors Affecting Ethylene Sensitivity in Plants, 17 Feb 2014 15:03:12 GMTotd@salk.edu Insensitive Plants, 17 Feb 2014 15:03:11 GMTotd@salk.edu Model for Studying Male Fertility and Stermatogenesis, 30 Jan 2014 12:54:06 GMTotd@salk.edu Factor Overproducing Transgenic Mice, 30 Jan 2014 10:50:11 GMTotd@salk.edu Packaging Cell Line Generating High-titer Vectors, 30 Jan 2014 10:50:11 GMTotd@salk.edu A Novel Gene for Extending Lifetime of Flowers and Fruits, 18 Jan 2014 14:45:58 GMTotd@salk.edu Mutant Coordinates Auxin and Ethylene Biosynthesis in Shade Avoidance Responses, 06 Jan 2014 12:53:44 GMTotd@salk.edu Cell Lines (GT1-1, 1-3 and 1-7), 24 Dec 2013 12:08:33 GMTotd@salk.edu mouse hippocampal cell line (HT22) mouse hippocampal cell line (HT22) INVENTION: Investigators from the Salk have developed an immortalized mouse hippocampal cell line, HT22, which is a sub-line derived from parent HT4 cells that were originally immortalized from primary mouse hippocampal neuronal culture. APPLICATIONS HT22 cells provide a model in vitro system to study glutamate cytotoxicity, a characteristic of many neurodegenerative disorders such as Alzheimer's Disease and Parkinson's Disease STAGE OF DEVELOPMENT: Cells are ready to transfer upon request INVENTORS: David Schubert ...Tue, 24 Dec 2013 12:08:32 GMTotd@salk.edu Nerve and Glial Cell Lines (B65, B103, B104) Nerve and Glial Cell Lines (B65, B103, B104) INVENTION: Investigators at the Salk have developed a number of cells lines from the rat central nervous system that display neuronal and glial characteristics and can be used to examine the distribution of neurotransmitter synthesis and brain-specific antigens amoung neurons and glial. APPLICATIONS These cells have been extensively used to study neuronal and glial-specific characteristics and to examine neuronal-glial interactions. STAGE OF DEVELOPMENT: Cells are ready for transport upon request INVENTORS: David Sch...Tue, 24 Dec 2013 12:08:32 GMTotd@salk.edu pituitary cell line producing a-FSH and a-LHRH pituitary cell line producing a-FSH and a-LHRH INVENTION: Investigators at the Salk have developed an immortalized anterior pituitary gonadotrope cell line by using directed expression of the SV40 T-antigen oncogene to specific cells in the anterior pituitary of transgenic mice using the promoter/enhancer region from teh human glycoprotein hormone alpha-subunit gene. Colonal cells lines established from these tumors express the endogenous mouse alpha-subunit gene and synthesize and secrete alpha-subunit protein. However, they do not express beta-subunit genes. Alpha-subunit...Tue, 24 Dec 2013 12:08:32 GMTotd@salk.edu pituitary cell line producing a-TSH Pituitary Cell Line Producing a-TSH INVENTION: The anterior pituitary contains multiple endocrine cell types that secrete individual hormones. Using the transplantable thyrotrope tumor MGH101A, investigators at the Salk have developed a clonal and continuous cell line in which to study the regulation of the alpha-subunit of thyrotropin (TSH) free of other hormones and cell types. This cell line expresses alpha-subunit mRNA and secretes alpha-subunit protein. These cells do not express the beta-subunit of TSH or respond to TRH or thyroid hormone. APPLICATION These cells a...Tue, 24 Dec 2013 12:08:31 GMTotd@salk.edu knock-out mice of Cell Adhesion (MOCA) Knock-out Mice INVENTION: Modifier of cell adhesion (MOCA) is a presenilin binding protein that functions as a guanine nucleotide exchange factor for Rac1. Investigators at the Salk have generated a moca knock-out mouse line which exhibits central axonal dystrophy, a concomitant loss of sensorimotor function and impaired axoplasmic flow - all of which are common pathalogical features of neurodegeneration. APPLICATIONS: moca-/- mice provide a novel model system to study the connections between distinct molecular and pathological features underlying c...Tue, 24 Dec 2013 12:08:31 GMTotd@salk.edu for Efficient Chondrogenic Differentiation, 10 Dec 2013 13:49:23 GMTotd@salk.edu of Brassinosteroid Levels in Plants; Enhancing Plant Size, Crop Yield and Stress Resistance of Brassinosteroid Levels in Plants; Enhancing Plant Size, Crop Yield and Stress Resistance Brassinosteroid insensitivity increases the biomass and grain production in most agriculture crops. INVENTION: Researchers at the Salk Institute have identified key components of the brassinosteroid biosynthesis and response pathways, which control growth and productivity in plants. Plant growth is coordinated by the intricate interplay between both external cues and internal mechanisms, and the brassinosteroid family of plant steroids plays an essential role regulating multiple aspe...Mon, 09 Dec 2013 11:03:46 GMTotd@salk.edu Zinc Protein That Controls Morning-specific Growth in Plants, 08 Dec 2013 15:08:48 GMTotd@salk.edu Amperometric Electrode, 25 Nov 2013 13:43:11 GMTotd@salk.edu Alternative to the Classical Method Mevalonate Biosynthetic Pathway for Renewable and Clean Synthesis of Isoprenoids, 22 Nov 2013 11:26:53 GMTotd@salk.edu Transgenic mice, 17 Nov 2013 15:22:05 GMTotd@salk.edu Transgenic Mice (PPARg-VP16 Tg), 16 Nov 2013 16:42:48 GMTotd@salk.edu Floxed Mice (Jackson Lab Strain 5897), 16 Nov 2013 15:36:25 GMTotd@salk.edu Embryonic Stem (ES) cells, 16 Nov 2013 15:03:11 GMTotd@salk.edu Platform for Cell Permeable Protein-Protein Interactions (PPI) Antagonists and Agonists, 15 Nov 2013 18:06:00 GMTotd@salk.edu Signatures to Standardize Manufacture of Induced Pluripotent Stem Cells, 06 Nov 2013 16:23:15 GMTotd@salk.edu Production Method Increases Stem Cell Yield, Safety, 06 Nov 2013 13:16:27 GMTotd@salk.edu Engineering in a Living Cell, 29 Oct 2013 16:22:25 GMTotd@salk.edu Reporter for Protein Phosphorylation, 29 Oct 2013 15:38:11 GMTotd@salk.edu of Heart Tissue Using miRNAs, 27 Oct 2013 16:31:35 GMTotd@salk.edu Method for Transgenic Animal Generation and Animal Cloning, 21 Oct 2013 12:34:17 GMTotd@salk.edu and Safer Method for Differentiation of Human Stem Cells, 15 Oct 2013 10:19:51 GMTotd@salk.edu Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells, 11 Oct 2013 08:56:29 GMTotd@salk.edu NNRTIs: More Therapeutic Options for the Treatment of HIV-1 AIDS, 24 Sep 2013 13:15:29 GMTotd@salk.edu mice for research use, 02 Sep 2013 16:18:51 GMTotd@salk.edu Tumor Mouse Models Using CRE Inducible Lentiviral Vectors, 26 Aug 2013 11:13:09 GMTotd@salk.edu platform VLP-based vaccine that combines antitoxin and vaccine--validated for anthrax, 18 Aug 2013 18:10:59 GMTotd@salk.edu null; b-gal knock-in mice, 18 Aug 2013 18:10:58 GMTotd@salk.edu Mice Expressing a Human SXR Receptor Polypeptide (Alb-hSXR-Tg and FABP-hSXR-Tg mice available), 18 Aug 2013 18:10:58 GMTotd@salk.edu Receptor Kinase for Enhacement of Plant Yields and Disease Resistance, 17 Aug 2013 16:59:28 GMTotd@salk.edu for Research Use, 13 Aug 2013 09:14:23 GMTotd@salk.edu Modified Plants: Modulated Flower Development, 11 Aug 2013 17:15:46 GMTotd@salk.edu deficient mice (Jackson Lab Strain 5091), 11 Aug 2013 13:42:15 GMTotd@salk.edu Biomarkers for Cancer-Causing Aneuploidy, 03 Aug 2013 17:00:51 GMTotd@salk.edu Transcription Regulators: Diagnosis and Treatment of Cell Proliferative Disorders, 02 Aug 2013 15:23:32 GMTotd@salk.edu A Novel Target for the Treatment of Catecholamine Related Diseases, 02 Aug 2013 15:23:31 GMTotd@salk.edu Neural Networks: Identifying Monosynaptic Connections, 12 Jul 2013 16:00:30 GMTotd@salk.edu Gamma Modulators for the Treatment of Metabolic Disorders, 12 Jul 2013 16:00:29 GMTotd@salk.edu Compounds for Treatment of Liposarcomas, 12 Jul 2013 16:00:29 GMTotd@salk.edu Transgene Expression using WPRE, 12 Jul 2013 16:00:27 GMTotd@salk.edu Against Bioterrorism: Inhibition of Poxvirus Growth, 10 Jul 2013 19:07:56 GMTotd@salk.edu Agonists: Blocking Neoplastic Cell Proliferation, 10 Jul 2013 19:07:56 GMTotd@salk.edu alpha -Deficient Animals and Cell Lines, 09 Jul 2013 17:41:55 GMTotd@salk.edu Improved Media: Differentiation, Maintenance, and Electrophysiological Evaluation of Neuronal Cultures, 09 Jul 2013 17:41:53 GMTotd@salk.edu knock-in mice, 28 Jun 2013 15:22:57 GMTotd@salk.edu Gene Modification in Mammalian Cells, 16 Jun 2013 15:34:33 GMTotd@salk.edu Corrected, Patient Specific iPS Cells for the Treatment of Blood Diseases (cMYC not required), 09 Jun 2013 17:52:22 GMTotd@salk.edu Progenitor Cells Generated from Cord Blood in 1-Step Progenitor Cells Generated from Cord Blood in 1-Step Development of cord blood induced neural-progenitor cells provides an alternative means to investigate cellular plasticity, drug screening and future cell replacement therapies. INVENTION: Salk Institute scientists have converted cord blood (CB) cells into neuronal progenitor-like cells by the forced expression of Sox2. The neural progenitor stem cells are self-renewing, express multiple neuronal markers in vitro, are able to differentiate in vitro and in vivo under permissive conditions into mature neurons that generate action...Fri, 08 Mar 2013 09:28:25 GMTotd@salk.edu