Salk Institute

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Search Results - Drug Discovery

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CNB-001- a novel synthetic pyrazole derivative of curcumin with neuroprotective, anti-oxidant and anti-inflammatory action
CNB-001 - a novel synthetic pyrazole derivative of curcumin with neuroprotective, anti-oxidant and anti-inflammatory action INVENTION: Investigators at the Salk Institute have designed, synthesized and optimized a novel pyrazole derivative of curcumin. CNB-001 displays much improved potency and metabolic stability over curcumin and is neuroprot...
Published: 4/10/2014   |   Inventor(s):  
Keywords(s): 5-lipoxygenase (5-LOX), Alzheimer's Disease, Amyloid-beta, Anti-oxidant, Asthma, Calcium Signaling, Drug Discovery, Neurodegenerative Disorders, Oxidative Stress, Parkinson's, Phosphatidylinositol 3'-kinase, Schubert, Stroke, tPA, Traumatic Brain Injury (TBI)
Category(s): Drug Discovery, Neurosciences and Ophthalmology
Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
Multicilin - a novel gene indispensible for multiciliate cell differentiation
Multicilin - a novel gene indispensible for multiciliate cell differentiation INVENTION:Studies at the Salk Institute have identified a novel gene crucial for the development of ciliated cells. Multicilin, a Notch-regulated, coiled-coil protein, is highly expressed in developing epithelia and activates the expression of genes required for mult...
Published: 3/28/2014   |   Inventor(s):  
Keywords(s): Asthma, Cilia, Cystic Fibrosis, Emphysema, FoxJ1, Infertility, Kintner, Respiratory
Category(s): Drug Discovery, Rare/Orphan Diseases, Research Reagents
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Corticotropin-Releasing Factor Overproducing Transgenic Mice Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels. INVENTION: This invention relates to a transgenic mouse model exhibiting chronic corticotropic-releasing factor (CRF) hypersecretion. These animals express high levels of adrenocorti...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): ACTH, Animal Models, Anorexia Nervosa, Anxiety, Corticotropin Releasing Factor, CRF, Cushing's, Glucocorticoid, Mouse Models, Reproduction, Vale
Category(s): Drug Discovery, Neurosciences and Ophthalmology, Research Reagents
Retroviral Packaging Cell Line Generating High-titer Vectors
Retroviral Packaging Cell Line Generating High-titer Vectors A tetracycline-regulated lentiviral packaging cell line that reproducibly generates helper-free, high-titer pseudotyped viral vectors capable of transducing non-dividing cells. INVENTION: Packaging cell lines can generate virus particles at very high titers. Another advantage of ...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Antivirals, Gene Expression, Gene Therapy, HIV, Verma, Virus
Category(s): Drug Discovery, Research Reagents
Hypothalamic Cell Lines (GT1-1, 1-3 and 1-7)
Hypothalamic Neuronal Mouse Cell Lines (GT1-1, 1-3 and 1-7) INVENTION: Investigators at the Salk have developed clonal, differentiated, neurosecretory cell lines. These cells extend neurites, express endogenous mouse GnRH mRNA, release GnRH in response to depolarization, have the regulatable fast Na+ channels found in neurons, and express neuro...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, GnRH, GT1-1, GT1-3, GT1-7, Mellon, Reproduction
Category(s): Drug Discovery, Research Reagents
PPAR-delta Floxed Mice (Jackson Lab Strain 5897)
PPAR-delta Floxed Mice (Jackson Lab Strain 5897) INVENTION: Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor-delta (PPAR-delta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPAR-delta -/- mice exhibit a striking reduction in adiposit...
Published: 11/16/2013   |   Inventor(s):  
Keywords(s): Adipocyte Differentiation, Cardiovascular Disease, Coronary Artery Disease, Drug Discovery, Evans, Hyperlipidemia, Lipid Metabolism, Mouse Models, Obesity, PPAR-delta
Category(s): Research Reagents, Cardiovascular, Drug Discovery, Inflammation
Screening Platform for Cell Permeable Protein-Protein Interactions (PPI) Antagonists and Agonists
Screening Platform for Cell Permeable Protein-Protein Interactions (PPI) Antagonists and Agonists Assay captures all three PPI antagonist classes: Interface Binder, Conformation Trapper, Allosteric Inducer. INVENTION: Drs. Leo Li and Geoffery Wahl at the Salk Institute have developed a novel screening platform for the characterization of PPI...
Published: 11/15/2013   |   Inventor(s):  
Keywords(s): Drug Discovery, Drug Efficacy, High Throughput Screens, Mdm2, Mdm4, p53, Protein-Protein Interactions, Proteins, Ras, Wahl
Category(s): Drug Discovery
Protein Engineering in a Living Cell
Protein Engineering in a Living Cell A method for engineering protein variants in living cells in a gene-specific manner. INVENTION: Invention is a method of gene-specific diversification or protein evolution in eukaryotic or prokaryotic cells. Polypeptide variants are generated in a living cell and can be rapidly identified. This tech...
Published: 10/29/2013   |   Inventor(s):  
Keywords(s): Antibodies, Directed Protein Evolution, Enzymes, Fluorescent Probes, Mutagenesis, Mutation, Protein Drug, Protein Engineering, Protein Modification, Proteins, Wang
Category(s): Drug Discovery, Research Reagents
Novel NNRTIs: More Therapeutic Options for the Treatment of HIV-1 AIDS
Novel Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of HIV-1 AIDS These NNRTIs substantially reduce the activity of HIV-1 reverse transcriptase and act synergistically with other existing retroviral inhibitors. INVENTION: During retrovirus infection, the virus uses the enzyme reverse transcriptase (RT) to transcribe its...
Published: 9/24/2013   |   Inventor(s):  
Keywords(s): AIDS, Antiretroviral Inhibitors, HAART Therapy, HIV, NNRTI, Noel, Non-Nucleoside Reverse Transcriptase, Retroviral Inhibitors, Young
Category(s): Infectious Diseases, Drug Discovery
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