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Search Results - animal models

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Mouse Model for Studying Male Fertility and Stermatogenesis
Mouse Model for Studying Male Fertility and Stermatogenesis Tony Hunter's laboratory at Salk Institute has generated transgenic mouse model in which males are sterile due to a block in spermatogenesis. INVENTION: The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis,...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Animal Models, Fertility, Hunter, Mouse Models, Phosphatidylinositol 3'-kinase, PI3K, Reproduction, Spermatogenesis, Stem Cell Factor
Category(s): Research Reagents
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Corticotropin-Releasing Factor Overproducing Transgenic Mice Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels. INVENTION: This invention relates to a transgenic mouse model exhibiting chronic corticotropic-releasing factor (CRF) hypersecretion. These animals express high levels of adrenocorti...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): ACTH, Animal Models, Anorexia Nervosa, Anxiety, Corticotropin Releasing Factor, CRF, Cushing's, Glucocorticoid, Mouse Models, Reproduction, Vale
Category(s): Drug Discovery, Neurosciences and Ophthalmology, Research Reagents
PPAR-gamma-Null Embryonic Stem (ES) cells
PPAR-gamma-Null Embryonic Stem (ES) cells INVENTION: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is highly expressed in lipid-accumulating macrophages of the coronary artery. In light of this, the wide-spread clinical use of thiazolidinediones (TZDs) in the treatment of type II diabetes raises concerns about the role of PPAR-...
Published: 11/16/2013   |   Inventor(s):  
Keywords(s): Animal Models, Cardiovascular Disease, Cell Lines, Coronary Artery Disease, Diabetes, Drug Discovery, Evans, iPSC, Lipid Metabolism, Mouse Models, Obesity, PPAR-Gamma
Category(s): Research Reagents, Cardiovascular, Inflammation, Metabolic Disorders
Novel Method for Transgenic Animal Generation and Animal Cloning
Novel Method of Transgenic Animal Generation and Animal Cloning Invention is based on a novel method of identification and isolation of cells in a two-cell (2C)-like state within embryonic stem cell populations or induced pluripotent stem cell populations. These 2C-like cells can be used for cloning or for generation of transgenic mice. ...
Published: 10/21/2013   |   Inventor(s):  
Keywords(s): Animal Cloning, Animal Models, Cloning, Pfaff, Stem Cells, Transgenic Animals, Transgenic Mice
Category(s): Regenerative Medicine, Research Reagents
Transgenic mice for research use
Animal Models for Research Use CONTACT: Michelle A. Booden, Ph.D., 858.453.4100 x1612, Click here for larger version>>
Published: 9/2/2013   |   Inventor(s):  
Keywords(s): Alzheimer's Disease, AML, Animal Models, Diabetes, FLP, Glioblastoma, Kinase Activity, Lipid Metabolism, Mouse Models, Obesity, Oncology
Category(s): Research Reagents
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