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Search Results - cell lines

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Hypothalamic Cell Lines (GT1-1, 1-3 and 1-7)
Hypothalamic Neuronal Mouse Cell Lines (GT1-1, 1-3 and 1-7) INVENTION: Investigators at the Salk have developed clonal, differentiated, neurosecretory cell lines. These cells extend neurites, express endogenous mouse GnRH mRNA, release GnRH in response to depolarization, have the regulatable fast Na+ channels found in neurons, and express neuro...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, GnRH, GT1-1, GT1-3, GT1-7, Mellon, Reproduction
Category(s): Drug Discovery, Research Reagents
Rat Nerve and Glial Cell Lines (B65, B103, B104)
Rat Nerve and Glial Cell Lines (B65, B103, B104) INVENTION: Investigators at the Salk have developed a number of cells lines from the rat central nervous system that display neuronal and glial characteristics and can be used to examine the distribution of neurotransmitter synthesis and brain-specific antigens amoung neurons and glial. APPLICAT...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): B103, B104, B65, Cell Lines, Glial, Neuronal, Schubert
Category(s): Research Reagents, Neurosciences and Ophthalmology
Gonadotropic pituitary cell line producing a-FSH and a-LHRH
Gonadotropic pituitary cell line producing a-FSH and a-LHRH INVENTION: Investigators at the Salk have developed an immortalized anterior pituitary gonadotrope cell line by using directed expression of the SV40 T-antigen oncogene to specific cells in the anterior pituitary of transgenic mice using the promoter/enhancer region from teh human glyc...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, Gonadotropin, Mellon, Reproduction
Category(s): Research Reagents
Thyrotropic pituitary cell line producing a-TSH
Thyrotropic Pituitary Cell Line Producing a-TSH INVENTION: The anterior pituitary contains multiple endocrine cell types that secrete individual hormones. Using the transplantable thyrotrope tumor MGH101A, investigators at the Salk have developed a clonal and continuous cell line in which to study the regulation of the alpha-subunit of thyrotro...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, Mellon, Reproduction, Thyrotropin
Category(s): Research Reagents
Peptides for Efficient Chondrogenic Differentiation
Peptides for Efficient Chondrogenic Differentiation Activin/BMP2 chimeric ligands that direct human adipose-derived stem cells to chondrogenic differentiation in a reproducible and highly efficient manner. INVENTION: Human adipose-derived stem cells (hASCs) can be easily isolated and their plasticity has been well characterized. Several TGF...
Published: 12/10/2013   |   Inventor(s):  
Keywords(s): Activin, Adipocyte Differentiation, Adipose Stem Cells, Adipose Tissue, Belmonte, BMP-2, Cartilage, Cartilage Damage, Cartilage Injury, Cartilage Repair, Cell Culture Media, Cell Lines, Chimeric Protein, Chondrocyte, Differentiation, Induced pluripotent stem cells, iPSC, Mesenchymal Stem Cells, Protein Modification, Proteins, Regenerative Medicine, Reprogramming, TGF
Category(s): Regenerative Medicine, Research Reagents
PPAR-gamma-Null Embryonic Stem (ES) cells
PPAR-gamma-Null Embryonic Stem (ES) cells INVENTION: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is highly expressed in lipid-accumulating macrophages of the coronary artery. In light of this, the wide-spread clinical use of thiazolidinediones (TZDs) in the treatment of type II diabetes raises concerns about the role of PPAR-...
Published: 11/16/2013   |   Inventor(s):  
Keywords(s): Animal Models, Cardiovascular Disease, Cell Lines, Coronary Artery Disease, Diabetes, Drug Discovery, Evans, iPSC, Lipid Metabolism, Mouse Models, Obesity, PPAR-Gamma
Category(s): Research Reagents, Cardiovascular, Inflammation, Metabolic Disorders
Fast Production Method Increases Stem Cell Yield, Safety
Fast Production Method Increases Stem Cell Yield, Safety Indirect lineage conversion of human cells has the potential to generate multiple cell lineages in an efficient and safe manner. INVENTION: Investigators at the Salk Institute have developed a faster and safer method for the generation of vascular progenitor cells from adult human fib...
Published: 11/6/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cardiovascular Disease, Cell Culture Media, Cell Lines, Equine Stem Cells, Indirect Lineage Conversion, Induced pluripotent stem cells, Ischemia, Lineage Conversion, Neural Stem Cells, Neurogenesis, Regenerative Medicine, Reprogramming, Stem Cells, Vascular disease, Vascular progenitor cells
Category(s): Regenerative Medicine, Cardiovascular, Animal Health
Faster and Safer Method for Differentiation of Human Stem Cells
Faster and Safer Method for Differentiation of Human Stem Cells Method also allows for unlimited expansion potential of stem cells without the use of feeder cells. INVENTION: Investigators at the Salk Institute have developed an efficient method for the directed differentiation of human embryonic stem cells (hES) and human induced pluripoten...
Published: 10/15/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cardiovascular Disease, Cell Culture Media, Cell Lines, Equine Stem Cells, Ischemia, Regenerative Medicine, Reprogramming, Stem Cells, Vascular disease, Vascular progenitor cells
Category(s): Cardiovascular, Regenerative Medicine, Animal Health
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells Method eliminates the need for SOX2 or OCT4 to generate human iPSCs from any somatic cell type. INVENTION: Investigators at the Salk Institute have developed a versatile method for reprogramming mature differentiated somatic cells into plurip...
Published: 10/11/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cell Culture Media, Cell Lines, c-MYC, Equine Stem Cells, Induced pluripotent stem cells, iPSC, KLF4, OCT4, Regenerative Medicine, Reprogramming, SOX2, Stem Cells
Category(s): Cardiovascular, Inflammation, Regenerative Medicine, Animal Health
RXR alpha -Deficient Animals and Cell Lines
Retinoid X Receptor (RXR) alpha-Deficient Animals and Cell Lines APPLICATIONS: These animals have a targeted loss-of-function mutation in the RXR alpha gene in the mouse germ line that results in embryonic lethality between E13.5 and E16.5 when bred to homozygosity. The major defect responsible for lethality is hypoplastic development of the...
Published: 7/9/2013   |   Inventor(s):  
Keywords(s): Cell Lines, Mouse Models
Category(s): Research Reagents
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