Salk Institute

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Search Results - diagnostics/biomarkers

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Adenoviral Tumor Diagnostics
Adenoviral Tumor Diagnostics Diagnostic viral reporters to define the malignant phenotype of tumors, and functionally determine their ability to respond to different therapies. INVENTION: Genome sequencing has accelerated our understanding of how molecular alterations determine a tumor's response to targeted drugs, ultimately leading to the ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Circulating Tumor Cells, Diagnostic, DNA Virus, Oncology, O'Shea, Personalized Medicine, Synthetic Biology, Tumors, Viral Reporters, Virus
Category(s): Diagnostics/Biomarkers, Oncology
Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
Multi-Species Amperometric Electrode
Multi-Species Amperometic Electrode - scaled for repeated, chronic use with minimal injury INVENTION: Investigators at the Salk have developed a novel multichannel amperometric electrode that can be used to make simulataneous recordings of the electrical activity of neurons and their immediate chemical environment APPLICATIONS: Analyte mea...
Published: 11/25/2013   |   Inventor(s):  
Keywords(s): Amperometry, Analytes, Disney, Electrode, Epilepsy, Measurement, Multi-channel, Multi-species, Neurochemical
Category(s): Diagnostics/Biomarkers, Neurosciences and Ophthalmology, Research Reagents
Fluorescent Reporter for Protein Phosphorylation
Fluorescent Reporter for Protein Phosphorylation A method to fluorescently report the phosphorylation status of a target substrate protein. INVENTION: Kinase activity can be monitored with fluorescent peptide-base or protein-based reporters, but no fluorescent reporter exists for the phosphorylation status of a substrate protein. Salk in...
Published: 10/29/2013   |   Inventor(s):  
Keywords(s): Fluorescent Probes, Fluorescent Reporter, Fluorsecence, Kinase, Kinase Activity, Nonnatural Ammino Acid, Phosphatase, Phosphatase Activity, Phosphorylation, SH2, STAT Proteins, STAT3, Unnatural Amino Acid, Wang
Category(s): Diagnostics/Biomarkers, Research Reagents
Two Biomarkers for Cancer-Causing Aneuploidy
Identification of Two Biomarkers for Cancer-Causing Aneuploidy Findings of disrupted micronuclei may prove to be a valuable tool for detecting cancer. INVENTION:Currently, few objective markers exist to detect genomic instability in solid tumors, although several cancers rely on the identification of aneuploidy. Retrospective studies by ...
Published: 8/3/2013   |   Inventor(s):  
Keywords(s): Aneuploidy, Bone Cancer, Hetzer, Lung Cancer, Melanoma, Micronuclei
Category(s): Diagnostics/Biomarkers, Oncology
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