Salk Institute

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Search Results - gene therapy

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Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
Retroviral Packaging Cell Line Generating High-titer Vectors
Retroviral Packaging Cell Line Generating High-titer Vectors A tetracycline-regulated lentiviral packaging cell line that reproducibly generates helper-free, high-titer pseudotyped viral vectors capable of transducing non-dividing cells. INVENTION: Packaging cell lines can generate virus particles at very high titers. Another advantage of ...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Antivirals, Gene Expression, Gene Therapy, HIV, Verma, Virus
Category(s): Drug Discovery, Research Reagents
Nurr1: A Novel Target for the Treatment of Catecholamine Related Diseases
Nurr1: A Novel Target for the Treatment of Catecholamine Related Diseases Nurr1 is a polypeptide that upregulates tyrosine hydroxylase activity and promotes expression of DOPA, epinephrine and norepinephrine. This could be useful for the treatment of catecholamine related diseases, such as Parkinson's, manic depression, and schizophrenia. I...
Published: 8/2/2013   |   Inventor(s):  
Keywords(s): Catecholamine, DOPA, Epinephrine, Gene Therapy, Manic depression, Neurodegenerative Disorders, norepinephrine, Nurr1, Parkinson's, Regenerative Medicine, Schizophrenia, Stem Cells, Tyrosine hydroxylase
Category(s): Regenerative Medicine, Neurosciences and Ophthalmology
Enhancing Transgene Expression using WPRE
Woodchuck Hepatitis Virus Response Element (WPRE) Increases Gene Expression from Retroviral Vectors Enhance transgene expression by promoting correct processing and transport of RNA from the cell nucleus to the cytoplasm. INVENTION: Salk Institute scientists have identified cis-acting RNA elements from the Woodchuck Hepatitis Virus (WHV) th...
Published: 7/12/2013   |   Inventor(s):  
Keywords(s): Gene Expression, Gene Therapy, Woodchuck Hepatitis Virus Response Eleme, WPRE
Category(s): Vaccines, Research Reagents
FLP-Mediated Gene Modification in Mammalian Cells
FLP-Mediated Gene Modification in Mammalian Cells Rapid and precise site-specific recombination in mammalian cells. INVENTION: Salk Institute scientists have developed methods for site-specific recombination of DNA in mammalian cells or host mammalian organisms based on the recombination of transfected sequences by FLP, a recombinase derived...
Published: 6/16/2013   |   Inventor(s):  
Keywords(s): Cell Lines, FLP, Gene Expression, Gene Therapy, Recombinase, Transgenes
Category(s): Research Reagents
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