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Search Results - inflammation

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PPAR-delta Floxed Mice (Jackson Lab Strain 5897)
PPAR-delta Floxed Mice (Jackson Lab Strain 5897) INVENTION: Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor-delta (PPAR-delta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPAR-delta -/- mice exhibit a striking reduction in adiposit...
Published: 11/16/2013   |   Inventor(s):  
Keywords(s): Adipocyte Differentiation, Cardiovascular Disease, Coronary Artery Disease, Drug Discovery, Evans, Hyperlipidemia, Lipid Metabolism, Mouse Models, Obesity, PPAR-delta
Category(s): Research Reagents, Cardiovascular, Drug Discovery, Inflammation
PPAR-gamma-Null Embryonic Stem (ES) cells
PPAR-gamma-Null Embryonic Stem (ES) cells INVENTION: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is highly expressed in lipid-accumulating macrophages of the coronary artery. In light of this, the wide-spread clinical use of thiazolidinediones (TZDs) in the treatment of type II diabetes raises concerns about the role of PPAR-...
Published: 11/16/2013   |   Inventor(s):  
Keywords(s): Animal Models, Cardiovascular Disease, Cell Lines, Coronary Artery Disease, Diabetes, Drug Discovery, Evans, iPSC, Lipid Metabolism, Mouse Models, Obesity, PPAR-Gamma
Category(s): Research Reagents, Cardiovascular, Inflammation, Metabolic Disorders
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells Method eliminates the need for SOX2 or OCT4 to generate human iPSCs from any somatic cell type. INVENTION: Investigators at the Salk Institute have developed a versatile method for reprogramming mature differentiated somatic cells into plurip...
Published: 10/11/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cell Culture Media, Cell Lines, c-MYC, Equine Stem Cells, Induced pluripotent stem cells, iPSC, KLF4, OCT4, Regenerative Medicine, Reprogramming, SOX2, Stem Cells
Category(s): Cardiovascular, Inflammation, Regenerative Medicine, Animal Health
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