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Search Results - oncology

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Anti-Cancer Adenoviruses
Rapid Generation of Customized Tumor-Selective Oncolytic Adenoviruses Allows for the efficient optimization of viruses for use in oncolytic viral therapies. INVENTION: The goal of oncolytic viral therapy is to specifically infect and kill tumor cells without causing damage to normal cells. Although adenovirus is one of the most commonly used ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Therapeutics, Cancer Vaccines, Oncology, Oncolytic Therapy, O'Shea, Personalized Medicine, Proliferative disorders, Synthetic Biology, Tumors, Vaccine, Viral Vectors, Virus
Category(s): Oncology
Oncolytic Viral Cancer Immunotherapy
Oncolytic Viral Cancer Immunotherapy Modular construction of targeted, systemically delivered oncolytic adenovirus for immunotherapy of cancer. INVENTION: Oncolytic viruses are exquisite tumor-selective, multi-mechanistic antitumor agents that can kill cancer cells, not just through direct oncolysis, but also via immunogenic cell death. These ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Therapeutics, Cancer Vaccines, Immunotherapies, Malignancy, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Viral Vectors
Category(s): Oncology
Adenoviral Tumor Diagnostics
Adenoviral Tumor Diagnostics Diagnostic viral reporters to define the malignant phenotype of tumors, and functionally determine their ability to respond to different therapies. INVENTION: Genome sequencing has accelerated our understanding of how molecular alterations determine a tumor's response to targeted drugs, ultimately leading to the ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Circulating Tumor Cells, Diagnostic, DNA Virus, Oncology, O'Shea, Personalized Medicine, Synthetic Biology, Tumors, Viral Reporters, Virus
Category(s): Diagnostics/Biomarkers, Oncology
Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
New Tumor Mouse Models Using CRE Inducible Lentiviral Vectors
Mouse Model of Glioblastoma Closely Mimicking Human Tumors A novel mouse model of glioblastoma with tumors generated in a region- and cell type-specific manner in a small number of cells in adult immunocompetent mice. INVENTION: This new method of glioblastoma is based on transduction of as few as 60 cells in the subventicular zone of hipp...
Published: 8/26/2013   |   Inventor(s):  
Keywords(s): Glioblastoma Multiforme, Lentiviral Vector, Mouse Models, Verma
Category(s): Drug Discovery, Research Reagents, Oncology
Two Biomarkers for Cancer-Causing Aneuploidy
Identification of Two Biomarkers for Cancer-Causing Aneuploidy Findings of disrupted micronuclei may prove to be a valuable tool for detecting cancer. INVENTION:Currently, few objective markers exist to detect genomic instability in solid tumors, although several cancers rely on the identification of aneuploidy. Retrospective studies by ...
Published: 8/3/2013   |   Inventor(s):  
Keywords(s): Aneuploidy, Bone Cancer, Hetzer, Lung Cancer, Melanoma, Micronuclei
Category(s): Diagnostics/Biomarkers, Oncology
FGF-2 Transcription Regulators: Diagnosis and Treatment of Cell Proliferative Disorders
FGF-2 Transcription Regulators: Diagnosis and Treatment of Cell Proliferative Disorders Invention is based on discovery of novel transcription factors that regulate fibroblast growth factor 2. INVENTION: Researchers at Salk have identified genes that encode polypeptides that are FGF-2 regulators of transcription (RFT). RFT-A is a negative regul...
Published: 8/2/2013   |   Inventor(s):  
Keywords(s): Alzheimer's Disease, Astrocytoma, Breast Cancer, Colon Cancer, Endometrial cancer, FGF, FGF-2, Gage, Glioblastoma, Glioma, Leukemia, Lung Cancer, Medulloblastoma, Melanoma, Neoplasia, Neoplastic Cell Proliferation, Neuroblastoma, Neurodegenerative Disorders, Oncology, Proliferative disorders, Prostate Cancer, Renal cancer, RFT, Screening methods, Testicular cancer, Tumors
Category(s): Drug Discovery, Oncology
Novel Compounds for Treatment of Liposarcomas
Novel Compounds for Treatment of Liposarcomas The Salk Institute is seeking companies interested in a combination of thiazolidinedionees and Retinoid X Receptor selective agonists that can be used to treat liposarcomas. INVENTION: Researchers at Salk Institute have found that PPAR gamma that is expressed consistently in each of the major his...
Published: 7/12/2013   |   Inventor(s):  
Keywords(s): Adipocyte Differentiation, Evans, Liposarcoma, PPAR-Gamma, Retinoid X Receptor Agonists, Thiazolidinedione
Category(s): Drug Discovery, Oncology
PPAR-gamma Agonists: Blocking Neoplastic Cell Proliferation
PPAR-gamma Agonists: Blocking Neoplastic Cell Proliferation Development of PPAR Gamma agonists that can block neoplastic cell proliferation. INVENTION: Researchers at Salk Institute have discovered that Retinoid X receptor (RXR)-specific ligands are potent agents for induction of differentiation of cells expressing the PPAR-gamma/RXR-alpha ...
Published: 7/10/2013   |   Inventor(s):  
Keywords(s): Breast Cancer, Colon Cancer, Evans, Leukemia, Neoplastic Cell Proliferation, PPAR-Gamma, Prostate Cancer, Retinoid X Receptor
Category(s): Drug Discovery, Oncology
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