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Peptides for Efficient Chondrogenic Differentiation
Peptides for Efficient Chondrogenic Differentiation Activin/BMP2 chimeric ligands that direct human adipose-derived stem cells to chondrogenic differentiation in a reproducible and highly efficient manner. INVENTION: Human adipose-derived stem cells (hASCs) can be easily isolated and their plasticity has been well characterized. Several TGF...
Published: 12/10/2013   |   Inventor(s):  
Keywords(s): Activin, Adipocyte Differentiation, Adipose Stem Cells, Adipose Tissue, Belmonte, BMP-2, Cartilage, Cartilage Damage, Cartilage Injury, Cartilage Repair, Cell Culture Media, Cell Lines, Chimeric Protein, Chondrocyte, Differentiation, Induced pluripotent stem cells, iPSC, Mesenchymal Stem Cells, Protein Modification, Proteins, Regenerative Medicine, Reprogramming, TGF
Category(s): Regenerative Medicine, Research Reagents
Epigenetic Signatures to Standardize Manufacture of Induced Pluripotent Stem Cells
Epigenetic Signatures to Standardize Manufacture of Induced Pluripotent Stem Cells The method allows for generating stem cells to good manufacturing practice (GMP) quality for clinical-grade cells. INVENTION: The reprogramming process, by which mature somatic cells acquire pluripotent cellular properties resembling those of embryonic stem ce...
Published: 11/6/2013   |   Inventor(s):  
Keywords(s): DNA methylation, Ecker, Epigenetics, GMP, Good manufacturing practice, Induced pluripotent stem cells, Manufacturing, Regenerative Medicine, Reprogramming, Stem cell quality control, Stem Cells
Category(s): Regenerative Medicine, Research Reagents
Fast Production Method Increases Stem Cell Yield, Safety
Fast Production Method Increases Stem Cell Yield, Safety Indirect lineage conversion of human cells has the potential to generate multiple cell lineages in an efficient and safe manner. INVENTION: Investigators at the Salk Institute have developed a faster and safer method for the generation of vascular progenitor cells from adult human fib...
Published: 11/6/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cardiovascular Disease, Cell Culture Media, Cell Lines, Equine Stem Cells, Indirect Lineage Conversion, Induced pluripotent stem cells, Ischemia, Lineage Conversion, Neural Stem Cells, Neurogenesis, Regenerative Medicine, Reprogramming, Stem Cells, Vascular disease, Vascular progenitor cells
Category(s): Regenerative Medicine, Cardiovascular, Animal Health
Regeneration of Heart Tissue Using miRNAs
Regeneration of Heart Tissue Using MicroRNAs Modulation of specific miRNAs after acute myocardial injury induced mature cardiomyocyte proliferation, diminished infarct size, and improved heart function. INVENTION: Investigators at the Salk Institute have identified miRNAs and their downstream targets, which regulate cadiomyocyte proliferatio...
Published: 10/27/2013   |   Inventor(s):  
Keywords(s): Belmonte, Cardiomyocyte regeneration, Cardiovascular Disease, Heart Failure, MicroRNA, Myocardial infarction, Regenerative Medicine, Reprogramming
Category(s): Cardiovascular, Regenerative Medicine
Faster and Safer Method for Differentiation of Human Stem Cells
Faster and Safer Method for Differentiation of Human Stem Cells Method also allows for unlimited expansion potential of stem cells without the use of feeder cells. INVENTION: Investigators at the Salk Institute have developed an efficient method for the directed differentiation of human embryonic stem cells (hES) and human induced pluripoten...
Published: 10/15/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cardiovascular Disease, Cell Culture Media, Cell Lines, Equine Stem Cells, Ischemia, Regenerative Medicine, Reprogramming, Stem Cells, Vascular disease, Vascular progenitor cells
Category(s): Cardiovascular, Regenerative Medicine, Animal Health
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells
Versatile Method for Producing Induced Pluripotent Stem Cells (iPSCs) from Any Somatic Starter Cells Method eliminates the need for SOX2 or OCT4 to generate human iPSCs from any somatic cell type. INVENTION: Investigators at the Salk Institute have developed a versatile method for reprogramming mature differentiated somatic cells into plurip...
Published: 10/11/2013   |   Inventor(s):  
Keywords(s): Belmonte, Canine Stem Cells, Cell Culture Media, Cell Lines, c-MYC, Equine Stem Cells, Induced pluripotent stem cells, iPSC, KLF4, OCT4, Regenerative Medicine, Reprogramming, SOX2, Stem Cells
Category(s): Cardiovascular, Inflammation, Regenerative Medicine, Animal Health
TLX null; b-gal knock-in mice
TLX null; b-gal knock-in mice INVENTION: Orphan nuclear receptor TLX is expressed in adult mammalian brains and critical in maintaining the proliferative state of neural stem cells. TLX knockout mice display impaired cell proliferation and reduced neural progenitors in neurogenic areas of adult brains. These animals could be used as tools t...
Published: 8/18/2013   |   Inventor(s):  
Keywords(s): Alzheimer's Disease, Evans, Gage, Mouse Models, Neurodegenerative Disorders, Neurons, Parkinson's, Regenerative Medicine, Schizophrenia, Stem Cells
Category(s): Research Reagents, Neurosciences and Ophthalmology, Regenerative Medicine
Nurr1: A Novel Target for the Treatment of Catecholamine Related Diseases
Nurr1: A Novel Target for the Treatment of Catecholamine Related Diseases Nurr1 is a polypeptide that upregulates tyrosine hydroxylase activity and promotes expression of DOPA, epinephrine and norepinephrine. This could be useful for the treatment of catecholamine related diseases, such as Parkinson's, manic depression, and schizophrenia. I...
Published: 8/2/2013   |   Inventor(s):  
Keywords(s): Catecholamine, DOPA, Epinephrine, Gene Therapy, Manic depression, Neurodegenerative Disorders, norepinephrine, Nurr1, Parkinson's, Regenerative Medicine, Schizophrenia, Stem Cells, Tyrosine hydroxylase
Category(s): Regenerative Medicine, Neurosciences and Ophthalmology
New Improved Media: Differentiation, Maintenance, and Electrophysiological Evaluation of Neuronal Cultures
New Improved Media: Differentiation, Maintenance, and Electrophysiological Evaluation of Neuronal Cultures BrainPhys is a novel media which improves differentiation and electrophysiological activity of neurons, supports long-term in vitro culture, mimics physiological conditions of the living brain, and allows for assessment of electrophysiolog...
Published: 7/9/2013   |   Inventor(s):  
Keywords(s): Calcium Signaling, Cell Culture Media, Cell Lines, Neurons, Patch Clamping, Regenerative Medicine, Reprogramming, Stem Cells
Category(s): Neurosciences and Ophthalmology, Regenerative Medicine, Research Reagents
Neural Progenitor Cells Generated from Cord Blood in 1-Step
Neural Progenitor Cells Generated from Cord Blood in 1-Step Development of cord blood induced neural-progenitor cells provides an alternative means to investigate cellular plasticity, drug screening and future cell replacement therapies. INVENTION: Salk Institute scientists have converted cord blood (CB) cells into neuronal progenitor-like cell...
Published: 3/8/2013   |   Inventor(s):  
Keywords(s): Neurons, Regenerative Medicine, Reprogramming, Stem Cells
Category(s): Regenerative Medicine, Neurosciences and Ophthalmology
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