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Search Results - research reagents

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Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
Multicilin - a novel gene indispensible for multiciliate cell differentiation
Multicilin - a novel gene indispensible for multiciliate cell differentiation INVENTION:Studies at the Salk Institute have identified a novel gene crucial for the development of ciliated cells. Multicilin, a Notch-regulated, coiled-coil protein, is highly expressed in developing epithelia and activates the expression of genes required for mult...
Published: 3/28/2014   |   Inventor(s):  
Keywords(s): Asthma, Cilia, Cystic Fibrosis, Emphysema, FoxJ1, Infertility, Kintner, Respiratory
Category(s): Drug Discovery, Rare/Orphan Diseases, Research Reagents
Lhx2 (LIM homeobox 2) conditional knock-out mice (Lhx2 floxed)
Lhx2 (LIM homeobox 2) conditional knock-out mice (Lhx2 floxed) APPLICATIONS: Selective deletion of floxed Lhx2 alleles by crossing with Cre lines for study of craniofacial, hematopoietic system, live/biliary system, nervous system, vision/eye. INVENTORS: Dennis D.M. O'Leary PUBLICATIONS: Nature Neuroscience (200...
Published: 3/28/2014   |   Inventor(s):  
Keywords(s): Mouse Models
Category(s): Research Reagents
Mouse Model for Studying Male Fertility and Stermatogenesis
Mouse Model for Studying Male Fertility and Stermatogenesis Tony Hunter's laboratory at Salk Institute has generated transgenic mouse model in which males are sterile due to a block in spermatogenesis. INVENTION: The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis,...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Animal Models, Fertility, Hunter, Mouse Models, Phosphatidylinositol 3'-kinase, PI3K, Reproduction, Spermatogenesis, Stem Cell Factor
Category(s): Research Reagents
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Corticotropin-Releasing Factor Overproducing Transgenic Mice Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels. INVENTION: This invention relates to a transgenic mouse model exhibiting chronic corticotropic-releasing factor (CRF) hypersecretion. These animals express high levels of adrenocorti...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): ACTH, Animal Models, Anorexia Nervosa, Anxiety, Corticotropin Releasing Factor, CRF, Cushing's, Glucocorticoid, Mouse Models, Reproduction, Vale
Category(s): Drug Discovery, Neurosciences and Ophthalmology, Research Reagents
Retroviral Packaging Cell Line Generating High-titer Vectors
Retroviral Packaging Cell Line Generating High-titer Vectors A tetracycline-regulated lentiviral packaging cell line that reproducibly generates helper-free, high-titer pseudotyped viral vectors capable of transducing non-dividing cells. INVENTION: Packaging cell lines can generate virus particles at very high titers. Another advantage of ...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Antivirals, Gene Expression, Gene Therapy, HIV, Verma, Virus
Category(s): Drug Discovery, Research Reagents
Hypothalamic Cell Lines (GT1-1, 1-3 and 1-7)
Hypothalamic Neuronal Mouse Cell Lines (GT1-1, 1-3 and 1-7) INVENTION: Investigators at the Salk have developed clonal, differentiated, neurosecretory cell lines. These cells extend neurites, express endogenous mouse GnRH mRNA, release GnRH in response to depolarization, have the regulatable fast Na+ channels found in neurons, and express neuro...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, GnRH, GT1-1, GT1-3, GT1-7, Mellon, Reproduction
Category(s): Drug Discovery, Research Reagents
Immortalized mouse hippocampal cell line (HT22)
Immortalized mouse hippocampal cell line (HT22) INVENTION: Investigators from the Salk have developed an immortalized mouse hippocampal cell line, HT22, which is a sub-line derived from parent HT4 cells that were originally immortalized from primary mouse hippocampal neuronal culture. APPLICATIONS HT22 cells provide a model in vitro system t...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Alzheimer's Disease, Cytotoxicity, Glutamate, HT22, Neuronal, Oxidative Stress, Parkinson's, Schubert
Category(s): Neurosciences and Ophthalmology, Research Reagents
Rat Nerve and Glial Cell Lines (B65, B103, B104)
Rat Nerve and Glial Cell Lines (B65, B103, B104) INVENTION: Investigators at the Salk have developed a number of cells lines from the rat central nervous system that display neuronal and glial characteristics and can be used to examine the distribution of neurotransmitter synthesis and brain-specific antigens amoung neurons and glial. APPLICAT...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): B103, B104, B65, Cell Lines, Glial, Neuronal, Schubert
Category(s): Research Reagents, Neurosciences and Ophthalmology
Gonadotropic pituitary cell line producing a-FSH and a-LHRH
Gonadotropic pituitary cell line producing a-FSH and a-LHRH INVENTION: Investigators at the Salk have developed an immortalized anterior pituitary gonadotrope cell line by using directed expression of the SV40 T-antigen oncogene to specific cells in the anterior pituitary of transgenic mice using the promoter/enhancer region from teh human glyc...
Published: 12/24/2013   |   Inventor(s):  
Keywords(s): Cell Lines, Gonadotropin, Mellon, Reproduction
Category(s): Research Reagents
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