Salk Institute

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Search Results - synthetic biology

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Anti-Cancer Adenoviruses
Rapid Generation of Customized Tumor-Selective Oncolytic Adenoviruses Allows for the efficient optimization of viruses for use in oncolytic viral therapies. INVENTION: The goal of oncolytic viral therapy is to specifically infect and kill tumor cells without causing damage to normal cells. Although adenovirus is one of the most commonly used ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Therapeutics, Cancer Vaccines, Oncology, Oncolytic Therapy, O'Shea, Personalized Medicine, Proliferative disorders, Synthetic Biology, Tumors, Vaccine, Viral Vectors, Virus
Category(s): Oncology
Adenoviral Tumor Diagnostics
Adenoviral Tumor Diagnostics Diagnostic viral reporters to define the malignant phenotype of tumors, and functionally determine their ability to respond to different therapies. INVENTION: Genome sequencing has accelerated our understanding of how molecular alterations determine a tumor's response to targeted drugs, ultimately leading to the ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Circulating Tumor Cells, Diagnostic, DNA Virus, Oncology, O'Shea, Personalized Medicine, Synthetic Biology, Tumors, Viral Reporters, Virus
Category(s): Diagnostics/Biomarkers, Oncology
VAS1 Mutant Coordinates Auxin and Ethylene Biosynthesis in Shade Avoidance Responses
Uncoupling Linked Auxin and Ethylene Biosynthetic Pathways in Plants; Increasing Crop Yields and Biomass Metabolic modulation of the shade avoidance syndrome (SAS), resulting in increased productivity, crop yield and biomass at high density planting. INVENTION: Investigators at the Salk Institute have engineered mutations in the VAS1 enzyme, ...
Published: 1/6/2014   |   Inventor(s):  
Keywords(s): Auxin, Chory, Disease Resistance, Enzymes, Ethylene, Floriculture, Fruit Production, Grains, Horticulture, Noel, Plant Biochemistry, Protein Engineering, Rice, Seeds, Soybeans, Synthetic Biology, Transgenic Organisms, VAS1, Vegetative Biomass, Wheat
Category(s): Plant Biology, Synthetic Biology
Metabolic Alternative to the Classical Method Mevalonate Biosynthetic Pathway for Renewable and Clean Synthesis of Isoprenoids
Metabolic Alternative to the Classical Method Mevalonate Biosynthetic Pathway for Renewable and Clean Synthesis of Isoprenoids The biosynthetic pathways allows for the renewable, clean, and high capacity synthesis of isoprenoid intermediates for use in fuels, lubricants, polymers/plastics, cosmetics, flavors/fragrances and other home and perso...
Published: 11/22/2013   |   Inventor(s):  
Keywords(s): Archaea, Biorenewables, Chloroflexi, Cosmetics, Enzymes, Flavors, Fragrances, Fuels, Isopentenyl Diphosphate, Isopentenyl Phosphate Kinase, Isoprenoids, Lipid Metabolism, Lubricants, Manufacturing, Metabolic Engineering, Metabolism, Mevalonate Pathway, Noel, Plant Biochemistry, Plastics, Polymers, Renewables, Synthetic Biology, Terpenes, Terpenoids
Category(s): Plant Biology, Biorenewables, Metabolic Engineering, Synthetic Biology
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