Salk Institute

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Search Results - virus

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Anti-Cancer Adenoviruses
Rapid Generation of Customized Tumor-Selective Oncolytic Adenoviruses Allows for the efficient optimization of viruses for use in oncolytic viral therapies. INVENTION: The goal of oncolytic viral therapy is to specifically infect and kill tumor cells without causing damage to normal cells. Although adenovirus is one of the most commonly used ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Therapeutics, Cancer Vaccines, Oncology, Oncolytic Therapy, O'Shea, Personalized Medicine, Proliferative disorders, Synthetic Biology, Tumors, Vaccine, Viral Vectors, Virus
Category(s): Oncology
Adenoviral Tumor Diagnostics
Adenoviral Tumor Diagnostics Diagnostic viral reporters to define the malignant phenotype of tumors, and functionally determine their ability to respond to different therapies. INVENTION: Genome sequencing has accelerated our understanding of how molecular alterations determine a tumor's response to targeted drugs, ultimately leading to the ...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Circulating Tumor Cells, Diagnostic, DNA Virus, Oncology, O'Shea, Personalized Medicine, Synthetic Biology, Tumors, Viral Reporters, Virus
Category(s): Diagnostics/Biomarkers, Oncology
Adenoviral Assembly Method
Modular Adenovirus Assembly Platform Custom, rapid and systematic assembly of recombinant adenoviral genomes from modular parts. INVENTION: Although adenoviral vectors are regularly used for the delivery of exogenous DNA to mammalian cells for basic science research, vaccines and gene therapy, the potential of adenoviral vectors in several ap...
Published: 4/9/2014   |   Inventor(s):  
Keywords(s): Adenovirus, Cancer Diagnostics, Cancer Therapeutics, Cancer Vaccines, DNA Virus, Gene Delivery, Gene Expression, Gene Therapy, Immunotherapies, Oncology, Oncolytic Therapy, O'Shea, Targeted Therapies, Vaccine, Viral Vectors, Virus
Category(s): Diagnostics/Biomarkers, Drug Discovery, Oncology, Regenerative Medicine, Research Reagents, Vaccines
Retroviral Packaging Cell Line Generating High-titer Vectors
Retroviral Packaging Cell Line Generating High-titer Vectors A tetracycline-regulated lentiviral packaging cell line that reproducibly generates helper-free, high-titer pseudotyped viral vectors capable of transducing non-dividing cells. INVENTION: Packaging cell lines can generate virus particles at very high titers. Another advantage of ...
Published: 1/30/2014   |   Inventor(s):  
Keywords(s): Antivirals, Gene Expression, Gene Therapy, HIV, Verma, Virus
Category(s): Drug Discovery, Research Reagents
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